The genie in the bottle-magnified calcium signaling in dorsolateral prefrontal cortex

Amy F. T. Arnsten, Dibyadeep Datta & Min Wang
Nature, Molecular Psychiatry, December 2020

Neurons in the association cortices are particularly vulnerable in cognitive disorders such as schizophrenia and Alzheimer’s disease, while those in primary visual cortex remain relatively resilient. This review proposes that the special molecular mechanisms needed for higher cognitive operations confer vulnerability to dysfunction, atrophy, and neurodegeneration when regulation is lost due to genetic and/or environmental insults.